84-5061-36　SIX1 (Homeobox Protein SIX1, Sine Oculis-related Homeobox 1 Homolog (Drosophila)) 100ul　491779

特徴

• Six1 is a transcription factor that is involved in regulation of organogenesis.
• It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation.
• It may be involved in limb tendon and ligament development.
• It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter.
• It is thought to be regulated by association with Dach and Eya proteins.
• Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2.
• Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex.
• During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.