84-5061-32　SIRT6 (NAD-dependent Protein Deacetylase Sirtuin-6) 100ul　491775

特徴

• SIRT6 is a NAD-dependent protein deacetylase.
• SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3.
• SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle.
• Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes.
• Deacetylation of nucleosomes interferes with RELA binding to target DNA.
• SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance.
• SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis.
• SIRT6 modulates cellular senescence and apoptosis.
• SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein.
• Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes.
• The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.
• Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
• The protein encoded by this gene is included in class IV of the sirtuin family.
• Applications:Suitable for use in Western Blot, Immunoprecipitation, CHIP.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.