84-5057-39　SEMA4D (Semaphorin-4D) 100ul　491386

特徴

• Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling.
• Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system.
• Regulates dendrite and axon branching and morphogenesis.
• Promotes the migration of cerebellar granule cells and of endothelial cells.
• Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro).
• Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.
• Interaction with PLXNB1 mediates activation of RHOA.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.