84-5049-12　RING1 (E3 Ebiquitin-protein Ligase RING1, Ring Finger Protein 1) 100ul　490566

特徴

• RING1 belongs to the RING finger family, members of which characterized by a RING domain, a zinc-binding motif related to the zinc finger domain.
• The protein can bind DNA and can act as a transcriptional repressor.
• It is associated with the multimeric polycomb group protein complex.
• RING1 interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains.
• It interacts with the CBX4 protein via its glycine-rich C-terminal domain.
• This gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain.
• The gene product can bind DNA and can act as a transcriptional repressor.
• It is associated with the multimeric polycomb group protein complex.
• The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains.
• It interacts with the CBX4 protein via its glycine-rich C-terminal domain.
• The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.