84-5048-59　RHOA 100ul　490513

特徴

• RHOA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
• It is involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.
• It plays an essential role in cleavage furrow formation.
• It is required for the apical junction formation of keratinocyte cell-cell adhesion.
• It may be an activator of PLCE1.
• Activated by ARHGEF2, which promotes the exchange of GDP for GTP.
• It is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
• The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.
• It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity.
• In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
• Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.