Ralb is a multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking.
Ralb accomplishes its multiple functions by interacting with distinct downstream effectors.
It acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles.
It is required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells.
Ralb plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis.
It is required for suppression of apoptosis.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes RALB. Species Crossreactivity: bovine, canine, goat, guinea pig, equine, human, mouse, rat, zebrafish
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Bo Ca Eq Gt Gp Hu Mo Rt Ze
Immunogen：Synthetic peptide corresponding to the middle region of Mouse Ralb
