84-5041-97　R1I3 (Nuclear Receptor Subfamily 1 Group I Member 3) 100ul　489858

特徴

• NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers.
• NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size.
• NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses.
• This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism.
• The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members.
• Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists.
• Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription.
• These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs.
• Multiple transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.