PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction.
It binds double-stranded DNA in a sequence-nonspecific manner.
PRPF19 acts as a structural component of the nuclear framework.
It may also serve as a support for spliceosome binding and activity.
It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability.
It also may have E3 ubiquitin ligase activity.
The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process.
Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S.
cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM].
Applications:Suitable for use in Immunohistochemistry, Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human PRPF19.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of human PRPF19
