84-5036-73　PRELP (Prolargin, Proline/Arginine-Rich end Leucine-Rich Repeat Protein) 100ul　489339

特徴

• PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix.
• This protein functions as a molecule anchoring basement membranes to the underlying connective tissue.
• This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage.
• It also binds the basement membrane heparan sulfate proteoglycan perlecan.
• This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix.
• This protein functions as a molecule anchoring basement membranes to the underlying connective tissue.
• This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage.
• It also binds the basement membrane heparan sulfate proteoglycan perlecan.
• This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.
• Alternatively spliced transcript variants encoding the same protein have been observed.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.