84-5030-15　PILRB (Paired Immunoglobulin-Like Type 2 Receptor Beta) 100ul　488687

特徴

• Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system.
• PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes.
• SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways.
• Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts.
• Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation.
• These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7.
• This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role.
• Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described.
• Additional transcript variants have been identified but their full-length nature has not been determined.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.