PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product.
The encoded protein plays a central role in development of the autonomic nervous system.
It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype.
PHOX2A has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product.
The encoded protein plays a central role in development of the autonomic nervous system.
It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype.
The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.
Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human PHOX2A.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the N-terminal region of human PHOX2A
