Pcsk1n may function in the control of the neuroendocrine secretory pathway.
It is proposed to be a specific endogenous inhibitor of PCSK1.
ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi.
It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1.
Subsequent processing of proSAAS may eliminate the inhibition.
Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin.
Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity.
The function of the processed secreted peptides is not known.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes rat PCSK1N.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to the N-terminal region of Rat Pcsk1n
