84-5022-79　PABPC4 (Polyadenylate-Binding Protein 4, Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) 100ul　487958

特徴

• Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
• PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein.
• Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold.
• PABPC4 contains 4 RNA-binding domains and proline-rich C terminus.
• PABPC4 is localized primarily to the cytoplasm.
• It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells.
• PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets.
• PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
• PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein.
• Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold.
• PABPC4 contains 4 RNA-binding domains and proline-rich C terminus.
• PABPC4 is localized primarily to the cytoplasm.
• It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells.
• PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets.
• PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
• PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein.
• Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold.
• PABPC4 contains 4 RNA-binding domains and proline-rich C terminus.
• PABPC4 is localized primarily to the cytoplasm.
• It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells.
• PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets.
• PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.