84-5017-63　OAS1 (2'-5'-Oligoadenylate Synthase 12'-5'-Oligoadenylate Synthetase 1, 40/46kD) 100ul　487447

特徴

• This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection.
• The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As).
• These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection.
• The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As).
• These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.
• The three known members of this gene family are located in a cluster on chromosome 12.
• Mutations in this gene have been associated with host susceptibility to viral infection.
• Alternatively spliced transcript variants encoding different isoforms have been described.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.