84-5017-19　NUP98 (Nuclear Pore Complex Protein Nup98-Nup96, Nucleoporin 98kD) 100ul　487403

特徴

• The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins.
• The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC.
• Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates.
• The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).
• This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region.
• Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.
• Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins.
• The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein.
• This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC.
• Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates.
• The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).
• This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region.
• Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.
• Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
• Applications:Suitable for use in Immunofluorescence, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.