84-5015-20　NR3C1 (Glucocorticoid Receptor, Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor)) 100ul　487206

特徴

• NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors.
• This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins.
• The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus.
• Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.
• The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors.
• This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins.
• The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus.
• Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.
• Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.