84-5014-92　NR2C1 (Nuclear Receptor Subfamily 2 Group C Member 1) 100ul　487179

特徴

• The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer.
• NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism.
• NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer.
• NR2C1 may exert an important repressor in regulating ER activity in mammary glands.
• The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily.
• This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes.
• Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.