Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction.
Vaults may also play a role in nucleo-cytoplasmic transport.
MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK.
MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein.
Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
This protein mediates drug resistance, perhaps via a transport process.
It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells.
The protein overexpression is a potentially useful marker of clinical drug resistance.
This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human MVP.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the N-terminal region of human MVP
