84-5006-21　MUC1 (Mucin Short Variant PC2 EMBL AAP97027.1, Mucin 1, Cell Surface Associated) 100ul　486316

特徴

• MUC1 is a membrane bound, glycosylated phosphoprotein.
• The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type.
• It also includes a 20aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals.
• The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.
• Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
• This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein.
• The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type.
• It also includes a 20aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals.
• The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.
• Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
• Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.