84-5004-46　MRPS12 (28S Ribosomal Protein S12, Mitochondrial, Mitochondrial Ribosomal Protein S12) 100ul　486143

特徴

• Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
• MRPS12 is the 28S subunit protein that belongs to the ribosomal protein S12P family.
• The protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics.Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion.
• Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
• They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
• Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
• Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology.
• This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family.
• The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics.
• The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4).
• Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.