84-5001-91　MLH3 (MutL Homolog 3 (E. coli) EMBL AAI12168.1, MutL Homolog 3 (E. coli)) 100ul　485891

特徴

• This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes.
• MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination.
• MLH3 functions as a heterodimer with other family members.
• Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7).
• Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes.
• MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination.
• The protein encoded by this gene functions as a heterodimer with other family members.
• Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7).
• Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.