This gene encodes a member of the MAP kinase family.
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
The activation of this kinase requires its phosphorylation by upstream kinases.
Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.
One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity.
The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions.
Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human MAPK1.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of human MAPK1
