KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3.
The cytoplasmic domains of these proteins interact with the C terminal of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762).
The cytoplasmic domains of these proteins interact with the C-terminal of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM].