KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes.
Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel.
The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD).
The functional channel is a homotetramer.
The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels.
The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting.
Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).
Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene.
This transcript is supported by sequences from mouse.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human KCNA1.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of human KCNA1
