84-4969-22　HERPUD1 (Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein, Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1) 100ul　482651

特徴

• The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response.
• This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system.
• This gene may play a role in both UPR and ERAD.
• Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system.
• This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression.
• Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
• The full-length nature of all transcript variants has not been determined.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.