84-4968-69　HDAC5 (Histone Deacetylase 5) 100ul　482599

特徴

• Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
• Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
• The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family.
• It possesses histone deacetylase activity and represses transcription when tethered to a promoter.
• It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins.
• It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes.
• This gene is thought to be associated with colon cancer.
• Two transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.