GTF2H2 gene is part of a 500kb inverted duplication on chromosome 5q13.
This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions.
The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region.
This gene is within the telomeric copy of the duplication.
Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype.
GTF2H2 is the 44kD subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair.
Transcript variants for this gene have been described, but their full length nature has not been determined.
A second copy of this gene within the centromeric copy of the duplication has been described in the literature.
It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.This gene is part of a 500kb inverted duplication on chromosome 5q13.
This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions.
The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region.
This gene is within the telomeric copy of the duplication.
Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype.
This gene encodes the 44kD subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair.
Transcript variants for this gene have been described, but their full length nature has not been determined.
A second copy of this gene within the centromeric copy of the duplication has been described in the literature.
It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human GTF2H2.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the N-terminal region of human GTF2H2
