Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif.
The 88kD precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor.
Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6kD peptides.
These smaller cleavage products are named granulin A, granulin B, granulin C, etc.
Epithelins 1 and 2 are synonymous with granulins A and B, respectively.
Both the peptides and intact granulin protein regulate cell growth.
However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth.
Granulin family members are important in normal development, wound healing, and tumorigenesis.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human GRN.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of Human GRN
