Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit.
These subunits are encoded by families of related genes.
This gene encodes a beta subunit.
Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity.
This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.
GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites.
Additional splice variants may exist for this gene, but they have not been fully described.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human GNB3.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the C-terminal region of Human GNB3
