84-4959-40　GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit, Glutamate-Cysteine Ligase EMBL BAE97618.1) 100ul　481679

特徴

• Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis.
• The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit.
• GCLC is the catalytic subunit of 637aa with a calculated molecular weight of 72.773kD.
• Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis.
• The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit.
• The gene encoding the catalytic subunit encodes a protein of 367aa with a calculated molecular weight of 72.773kD and maps to chromosome 6.
• The regulatory subunit is derived from a different gene located on chromosome 1p22-p21.
• Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.