84-4956-55　FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Fat Mass and Obesity Associated) 100ul　481397

特徴

• Fto is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation.
• Fto has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine.
• Fto has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine.
• Fto has no activity towards 1-methylguanine and no detectable activity towards double-stranded DNA.
• Fto requires molecular oxygen, alpha-ketoglutarate and iron.
• Fto contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis.
• Fto contributes to the regulation of body size and body fat accumulation.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.