84-4951-13　FBL (rRNA 2'-O-Methyltransferase Fibrillarin, Fibrillarin) 100ul　480860

特徴

• FBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA.
• It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus.
• FBL contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species.
• Its central region resembles an RNA-binding domain and contains an RNP consensus sequence.
• Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA.
• It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus.
• The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species.
• Its central region resembles an RNA-binding domain and contains an RNP consensus sequence.
• Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.