84-4945-70　ERCC5 (DNA Repair Protein Complementing XP-G Cells, Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 5) 100ul　480323

特徴

• This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage.
• The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair.
• Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure.
• Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia.
• Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.