84-4944-91　EPB49 (Dematin, Dematin Actin Binding Protein) 100ul　480245

特徴

• The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner.
• This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin.
• When purified from erythrocytes, this protein exists as a trimer composed of two 48kD polypeptides and a 52kD polypeptide.
• The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located.
• Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression.
• Alternative splicing results in multiple transcript variants encoding different isoforms.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.