ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family.
ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors.
In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells.
ELF3 is expected to be a critical regulator of epithelial cell differentiation.
ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation.
ELF3 overexpressed early during human breast tumorigenesis.
ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells.
ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis.
ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human ELF3.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of human Elf3
