84-4940-91　EBP (3-Beta-Hydroxysteroid-Delta(8),Delta(7)- Isomerase, Emopamil Binding Protein (Sterol Isomerase)) 100ul　479849

特徴

• EBP is an integral membrane protein of the endoplasmic reticulum.
• It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil.
• It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues.
• These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein.
• Mutations in EBP gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).Emopamil-binding protein (EBP) is an integral membrane protein of the endoplasmic reticulum.
• It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil.
• It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues.
• EBP shares structural features with bacterial and eukaryontic drug transporting proteins.
• It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics.
• Another prominent feature of EBP is its high content of aromatic amino acid residues (>23%) in its transmembrane segments.
• These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein.
• Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.