84-4940-56　E2F4 (Transcription Factor E2F4) 100ul　479814

特徴

• The protein encoded by this gene is a member of the E2F family of transcription factors.
• The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins.
• It is also a target of the transforming proteins of small DNA tumor viruses.
• The E2F proteins contain several evolutionally conserved domains found in most members of the family.
• These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.
• This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two.
• It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.