84-4938-15　DNMT3B (DNA (Cytosine-5)-Methyltransferase 3B, DNA (Cytosine-5-)-Methyltransferase 3 Beta) 100ul　479575

特徴

• DNMT3B is required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development.
• DNA methylation is coordinated with methylation of histones.
• DNMT3B may preferentially methylate nucleosomal DNA within the nucleosome core region.
• DNMT3B may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation.
• DNMT3B seems to be involved in gene silencing.
• In association with DNMT1 and via the recruitment of CTCFL/BORIS, DNMT3B is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
• CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation.
• Studies in mice have demonstrated that DNA methylation is required for mammalian development.
• This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation.
• The protein localizes primarily to the nucleus and its expression is developmentally regulated.
• Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
• Six alternatively spliced transcript variants have been described.
• The full length sequences of variants 4 and 5 have not been determined.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.