84-4933-89　DDIT4 (DNA Damage-Inducible Transcript 4 Protein) 100ul　479154

特徴

• Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1).
• Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB.
• Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage.
• Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity.
• Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity).
• Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).
• Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity.
• Required for normal neuron migration during embryonic brain development.
• Plays a role in neuronal cell death.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.