84-4933-71　DCX (Neuronal Migration Protein Doublecortin, Doublecortin) 100ul　479136

特徴

• In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation.
• DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules.
• The protein contains two doublecortin domains, which bind microtubules.
• In addition, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation.
• The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules.
• The encoded protein contains two doublecortin domains, which bind microtubules.
• In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.
• Mutations in this gene are a cause of X-linked lissencephaly.
• Multiple transcript variants encoding at least three different isoforms have been found for this gene.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.