84-4931-41　CYP1A1 (Cytochrome P450 1A1, Cytochrome P450, Family 1, Subfamily A, Polypeptide 1) 100ul　478907

特徴

• CYP1A1 is a member of the cytochrome P450 superfamily of enzymes.
• The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
• This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
• The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates.
• CYP1A1 has been associated with lung cancer risk.
• This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes.
• The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
• This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
• The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates.
• The gene has been associated with lung cancer risk.
• A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
• Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly.
• The genomic coordinates used for the transcript record were based on alignments.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.