Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
CSNK1E can phosphorylate a large number of proteins.
CSNK1E participates in Wnt signaling and is the central component of the circadian clock.
It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2.
CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair.
The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself.
This protein has been shown to phosphorylate period, a circadian rhythm protein.
Two transcript variants encoding the same protein have been found for this gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human CSNK1E.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the N-terminal region of human CSNK1E
