84-4926-25　COPS5 (COP9 Signalosome Complex Subunit 5) 100ul　478395

特徴

• COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways.
• The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome.
• COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
• This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1.
• It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
• The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways.
• The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome.
• COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
• This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1.
• It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.