84-4925-33　CNTNAP2 (Contactin-Associated Protein-Like 2) 100ul　478303

特徴

• This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors.
• This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains.
• In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site.
• This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.
• This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome.
• It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development.
• This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.