Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits.
CHRNB3 is one of the subunits of nAChR.
Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4.
CHRNB3 decreased the channel mean open time and burst length.
There was also an increase in single channel slope conductance.
On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3.
Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases.
nAChRs also play a significant role in nicotine addiction.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes CHRNB3.
Isotype：IgG
Calc Applications Abbrev：WB
Immunogen：Synthetic peptide corresponding to the middle region of human CHRNB3
