84-4922-18　CHRNA4 (Neuronal Acetylcholine Receptor Subunit Alpha-4, Cholinergic Receptor, Nicotinic, Alpha 4 (Neuronal)) 100ul　477991

特徴

• CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses.
• These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane.
• This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.
• Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.
• Polymorphisms in this gene that provide protection against nicotine addiction have been described.
• This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses.
• These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane.
• This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.
• Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.
• Polymorphisms in this gene that provide protection against nicotine addiction have been described.
• Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly.
• The genomic coordinates used for the transcript record were based on transcript alignments.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.