84-4920-41　CEP57 100ul　477816

特徴

• This gene encodes a cytoplasmic protein called Translokin.
• This protein localizes to the centrosome and has a function in microtubular stabilization.
• The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes.
• This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2.
• It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells.
• This protein is crucial for maintaining correct chromosomal number during cell division.
• Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder.
• Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.