84-4918-39　CDH1 (Cadherin-1, Cadherin 1, Type 1, E-Cadherin (Epithelial)) 100ul　477616

特徴

• Cadherins are calcium-dependent cell adhesion proteins.
• They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
• CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells.
• Has a potent invasive suppressor role.
• It is a ligand for integrin alpha-E/beta-7.This gene is a classical cadherin from the cadherin superfamily.
• The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail.
• Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer.
• Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis.
• The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.
• Identified transcript variants arise from mutation at consensus splice sites.
• Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene.
• The extent of this transcript is supported by transcript alignments.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.