BCL11B is the tumor-suppressor protein involved in T-cell lymphomas.
BCL11B may function on the P53-signaling pathway.
BCL11B may be a key regulator of both differentiation and survival during thymocyte development.
BCL11B repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies.
The specific function of this gene has not yet been determined.
Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Applications:Suitable for use in Immunohistochemistry, Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human BCL11B.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of human BCL11B
