84-4900-52 ATG14 (Beclin 1-Associated Autophagy-Related Key Regulator, Autophagy Related 14) 100ul 475845
特徴
- Required for both basal and inducible autophagy.
- Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1.
- Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine.
- Promotes BECN1 translocation from the trans-Golgi network to autophagosomes.
- Enhances PIK3C3 activity in a BECN1-dependent manner.
- Essential for the autophagy-dependent phosphorylation of BECN1.
- Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK.
- Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion.
- Modulates the hepatic lipid metabolism.
- Applications:Suitable for use in Western Blot.
- Other applications not tested.
- Recommended Dilution:Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by affinity chromatography.
- Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
- Specificity：Recognizes human ATG14.
- Isotype：IgG
- Calc Applications Abbrev：WB
- Calc Crossreactivity：Hu
- Immunogen：Synthetic peptide corresponding to the middle region of human ATG14
- Shelf Life：1year
- Swiss Prot Number：Q6ZNE5
- EU Commodity Code：30021010
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